SR proteins are essential for the splicing of messenger RNA precursors in vitro, where they also alter splice site selection in a concentration‐dependent manner. Although experiments involving overexpression or dominant mutations have confirmed that these proteins can influence RNA processing decisions in vivo, similar results with loss‐of‐function mutations have been lacking. Now, a system for genetic depletion of the chicken B cell line DT40 has revealed that the SR protein ASF/SF2 (alternative splicing factor/splicing factor 2) is essential for viability in (...) these cells(1). This study opens the way for a complete functional dissection of this protein, and other SR proteins, in vivo. (shrink)

n one of the numerous movie versions of A Christmas Carol , Ebenezer Scrooge, mounting the steps to visit his dying partner, Jacob Marley, encounters a dignified gentleman sitting on a landing. "Are you the doctor?" Scrooge inquires. "No," replies the man, "I'm the undertaker; ours is a very competitive business." The cutthrought world of intellectuals must rank a close second, and few events attract more notice than a proclamation that popular ideas have died. Darwin's theory of natural selection has (...) been a perennial candidate for burial. (shrink)

It is widely assumed that disability is typically a bad thing for those who are disabled. Our purpose in this essay is to critique this view and defend a more nuanced picture of the relationship between disability and well-being. We first examine four interpretations of the above view and argue that it is false on each interpretation. We then ask whether disability is thereby a neutral trait. Our view is that most disabilities are neutral in one sense, though we cannot (...) make simple generalizations about disability's relationship to well-being in other important senses. After defending this view, we discuss its practical implications for selective abortion for disability, nondisabled people's interactions with disabled people, and the use of QALYs in health policy. (shrink)

Fisher’s 1918 paper accomplished two distinct goals: unifying discrete Mendelian genetics with continuous biometric phenotypes and quantifying the variance components of variation in complex human characteristics. The former contributed to the foundation of modern quantitative genetics; the latter was adopted by social scientists interested in the pursuit of Galtonian nature-nurture questions about the biological and social origins of human behavior, especially human intelligence. This historical divergence has produced competing notions of the estimation of variance ratios referred to as heritability. Jay (...) Lush showed that they could be applied to selective breeding on the farm, while the early twin geneticists used them as a descriptive statistic to describe the degree of genetic determination in complex human traits. Here we trace the early history of the heritability coefficient now used by social scientists. (shrink)

Lucas Matthews and I substantially revised my SEP entry on Heritability. This version includes discussion of the missing heritability problem and other issues that arise from the use of Genome Wide Association Studies by Behavioral Geneticists.

On the traditional view, moral distress arises only in cases where an individual believes she knows the morally right thing to do but fails to perform that action due to various constraints. We seek to motivate a broader understanding of moral distress. We begin by presenting six types of distress that fall outside the bounds of the traditional definition and explaining why they should be recognized as forms of moral distress. We then propose and defend a new and more expansive (...) definition of moral distress and examine how it can enable the development of a taxonomy of moral distress. (shrink)

A critical study of two recent books in climate ethics by Dale Jamieson (Reason in a Dark Time, Oxford 2014), and Darrel Moellendorf (The Moral and Political Challenges of Climate Change, Cambridge 2014).

This is an updated version of my Stanford Encyclopedia entry on Evolutionary Psychology. The 2018 version contains a new section on Human Nature as well as some new material on recent developments in Evolutionary Psychology.

ABSTRACT In Debating Climate Ethics, David Weisbach and I offer contrasting views of the importance of ethics and justice for climate policy. I argue that ethics is central. Weisbach advocates for climate policy based purely on narrow forms of self-interest. For this symposium, I summarize the major themes, and extend my basic argument. I claim that ethics gets the problem right, whereas dismissing ethics risks getting the problem dangerously wrong, and perpetuating profound injustices. One consequence is that we should reject (...) the alleged “feasibility constraint” of short-term, economic self-interest. (shrink)

This long-awaited work by prominent Harvard psychologist Stephen Kosslyn integrates a twenty-year research program on the nature of high-level vision and mental ...

ABSTRACTThis article offers a constructive critique of the Oxford Principles for the governance of geoengineering and proposes an alternative set of principles, the Tollgate Principles, based on that critique. Our main concern is that, despite their many merits, the Oxford Principles remain largely instrumental and dominated by procedural considerations; therefore, they fail to lay the groundwork sufficiently for the more substantive ethical debate that is needed. The article aims to address this gap by making explicit many of the important ethical (...) questions lurking in the background, especially around values such as justice, respect and legitimacy. (shrink)

Variability of aggression: human aggressive behavior varies on a number of dimensions. We argue that this variability is best understood through an interdisciplinary evolutionary approach.

In two celebrated and widely-anthologized articles, as well as several books, the biologist Garrett Hardin claims (a) that the world population problem has a certain structure – it is a tragedy of the commons - and, (b) that, given this structure, the only tenable solutions involve either coercion or immense human suffering. In this paper, I shall argue for two claims. First, Hardin’s arguments are deeply flawed. The population problem as he conceives it does not have the structure of a (...) commons; and even if it did, this would not necessitate the extreme responses he canvasses. Second, nevertheless, much of Hardin’s pessimism is justified. Some environmental problems associated with population do have tragic structures, though these are of a different form than Hardin envisions. For example, the problem of global climate change has an intergenerational aspect that makes it importantly worse than Hardin’s commons, and for this reason (as opposed to Hardin’s) extreme responses may be needed to avert environmental catastrophe. (shrink)

The so-called Disability Paradox arises from the apparent tension between the popular view that disability leads to low well-being and the relatively high life-satisfaction reports of disabled people. Our aim in this essay is to make some progress toward dissolving this alleged paradox by exploring the relationship between disability and various “goods of life”—that is, components of a life that typically make a person’s life go better for her. We focus on four widely recognized goods of life (happiness, rewarding relationships, (...) knowledge, achievement) and four common types of disability (sensory, mobility, intellectual, and social) and systematically examine the extent to which the four disability types are in principle compatible with obtaining the four goods of life. Our findings suggest that that there is a high degree of compatibility. This undermines the widespread view that disabilities, by their very nature, substantially limit a person’s ability to access the goods of life, and it provides some guidance on how to dissolve the Disability Paradox. (shrink)

Disability and enhancement are often treated as opposing concepts. To become disabled in some respect is to move away from those who are enhanced in that same respect; to become enhanced is to move away from the corresponding state of disability. This chapter examines how best to understand the concepts of disability and enhancement in this symmetrical way. After considering various candidates, two types of accounts are identified as the most promising: welfarist accounts and typical-functioning accounts. The authors ultimately defend (...) a complex typical-functioning account as the best way to achieve a symmetrical understanding of disability and enhancement. (shrink)

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns in The Wanderer in 2021. In it, he explains the need to in an organized manner oppose the left and how, in a general way, it needs to be done. This article is reprinted with permission.

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns in The Wanderer in 2021. In it, he says that in spite of the left’s irresponsible claims about “systemic racism” in America, motivated by their ideological objectives, they pay little attention to the real problems in the Black community such as illegitimacy, family breakdown, and fatherlessness. This article is reprinted with permission.

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns in The Wanderer in 2021. In it, he writes that the Democratic party has increasingly embraced the agenda of the left, been tolerant of violence by radical organizations, been willing to compromise the principle of the rule of law, and shown increasing intolerance of opposing perspectives and a tendency to political repression. This article is reprinted with permission.

The Carnegie Council's work “is rooted in the premise that the incorporation of ethical concerns into discussions of international affairs will yield more effective policies both in the United States and abroad.” In honor of the Council's centenary, we have been asked to present our views on the ethical and policy issues posed by climate change, focusing on what people need to know that they probably do not already know, and what should be done. In that spirit, this essay argues (...) that climate change poses a profound ethical challenge, that the ongoing evasion of this challenge produces ineffective policy, and, therefore, that a fundamental paradigm shift is needed. More specifically, I maintain that the climate problem is usually misdiagnosed as a traditional tragedy of the commons, that this obscures two deeper and distinctively ethical challenges, and that we should address these challenges head on, by calling for a global constitutional convention focused on future generations. (shrink)

This paper argues that extortion is a clear threat in intergenerational relations, and that the threat is manifest in some existing proposals in climate policy and latent in some background tendencies in mainstream moral and political philosophy. The paper also claims that although some central aspects of the concern about extortion might be pursued in terms of the entitlements of future generations, this approach is likely to be incomplete. In particular, intergenerational extortion raises issues about the appropriate limits to the (...) sway of central values such as welfare and distributive justice. We should be wary of ways in which such values invite us to buy off, or perhaps to join, an intergenerational climate Mafia. (shrink)

Existing institutions do not seem well-designed to address paradigmatically global, intergenerational and ecological problems, such as climate change. 1 In particular, they tend to crowd out intergenerational concern, and thereby facilitate a “tyranny of the contemporary” in which successive generations exploit the future to their own advantage in morally indefensible ways (albeit perhaps unintentionally). Overcoming such a tyranny will require both accepting responsibility for the future and meeting the institutional gap. I propose that we approach the first in terms of (...) a traditional “delegated responsibility” model of the transmission of individual responsibility to collectives, and the second with a call for a global constitutional convention focused on future generations. In this paper, I develop the delegated responsibility model by suggesting how it leads us to understand both past failures and prospective responsibility. I then briefly defend the call for a global constitutional convention. (shrink)

Ethics is highly relevant to grand technological interventions into basic planetary systems on a global scale (roughly, “geoengineering”). Focusing on climate engineering, this chapter identifies a large number of salient concerns (e.g., welfare, rights, justice, political legitimacy) but argues that early policy framings (e.g., emergency, global public good) often marginalize these and so avoid important questions of justification. It also suggests that, since it is widely held that geoengineering has become a serious option mainly because of political inertia, there are (...) important contextual issues, especially around the paradoxical question, “What should we do, ethically speaking, given that we have not done, and will continue not to do, what we should be doing?” Taking such issues seriously helps to explain why some regard geoengineering as ethically troubling and highlights the largely neglected threat of interventions that discriminate against future generations (“parochial geoengineering”). We should take seriously the risk that, far from being simply a welcome new tool for climate action, geoengineering may become yet another manifestation of the underlying problem. (shrink)

Climate change is a global problem that is predominantly an intergenerational conflict, and which takes place in a setting where our ethical impulses are weak. This "perfect moral storm" poses a profound challenge to humanity. This book explains how the "perfect storm" metaphor makes sense of our current malaise, and why a better ethics can help see our way out.

In 2001, 178 of the world's nations reached agreement on a treaty to combat global climate change brought on by anthropogenic emissions of greenhouse gases. Despite the notable omission of the United States, representatives of the participants, and many newspapers around the world, expressed elation. Margot Wallström, the environment commissioner of the European Union, went so far as to declare, “Now we can go home and look our children in the eye and be proud of what we have done.”In this (...) article, I argue for two theses. First, the rhetoric and euphoria surrounding the 2001 deal is misplaced. This is not, as is often said, because the Kyoto agreement is too demanding but rather because it is much too weak. In particular, the Kyoto agreement does little to protect future generations. On the contrary, (at best) it seems to be a prudent wait-and-see policy for the present generation, narrowly defined. Hence, even those countries who have endorsed the Kyoto agreement should be wary of looking their children in the eye, and none should relish facing their children's children.Second, the failure of the Kyoto agreement can be explained in terms of the underlying structure of the problem. Climate change involves the intersection of a complex set of intergenerational and intragenerational collective action problems. This structure, and in particular its intergenerational aspect, has not been adequately appreciated. Yet until it is, we are doomed to an ineffectual environmental policy. (shrink)

We argue that heritability estimates cannot be used to make informed judgments about the populations from which they are drawn. Furthermore, predicting changes in heritability from population changes is likely impossible, and of limited value. We add that the attempt to separate human environments into cultural and non-cultural components does not advance our understanding of the environmental multiplier effect.

A cutting-edge introduction to environmental ethics in a time of dramatic global environmental change, this collection contains forty-five newly commissioned articles, with contributions from well-established experts and emerging voices in the field.

This handbook is currently in development, with individual articles publishing online in advance of print publication. At this time, we cannot add information about unpublished articles in this handbook, however the table of contents will continue to grow as additional articles pass through the review process and are added to the site. Please note that the online publication date for this handbook is the date that the first article in the title was published online. For more information, please read the (...) site FAQs. (shrink)

Recently, I have been arguing for a global constitutional convention focused on protecting future generations. This deliberative body would be akin to the American constitutional convention of 1787, which gave rise to the present structure of government in the United States. It would confront the “governance gap” that currently exists surrounding concern for future generations. In particular, contemporary institutions tend to crowd out intergenerational concern, and thereby facilitate a “tyranny of the contemporary.” They not only fail to address a basic (...) standing threat to humanity and other species, but help that threat become manifest. Climate change is a prime example. In this paper, I sketch out a natural argumentative path toward the global constitutional convention and argue that is difficult to resist. I also insist that we should be evenhanded in the way we treat the proposal. Those who put their faith in alternatives must also confront standard complaints about naivety, urgency, threats to democratic values, and the like. Moreover, the global constitutional convention has the advantage of addressing the problem we face head on. (shrink)

It is commonly thought that disability is a harm or “bad difference” because having a disability restricts valuable options in life. In his recent essay “Disability, Options and Well-Being,” Thomas Crawley offers a novel defense of this style of reasoning and argues that we and like-minded critics of this brand of argument are guilty of an inconsistency. Our aim in this article is to explain why our view avoids inconsistency, to challenge Crawley's positive defense of the Options Argument, and to (...) suggest that this general line of reasoning employs a double standard. (shrink)

There is widespread agreement that ethical concerns are central to decision-making about, and governance of, geoengineering. This is especially true of the most prominent and paradigm example of climate engineering, the spraying of sulfate particles into the stratosphere in order to block incoming sunlight and so limit global warming ). Geoengineering ethics, like geoengineering science, is still in its early, exploratory days. This chapter offers an introductory overview of the emerging discussion and some of the challenges moving forward, taking SSI (...) as its key example. It identifies a range of values relevant to geoengineering, exposes some misleading early framings, argues that questions of justification and context are both important, and summarizes the Tollgate principles for geoengineering governance. One theme is that despite the initial agreement on the centrality of ethics, in practice there are profound risks that ethical considerations will be marginalized, both in the short-term as research is developed, and in the longer-run, in any deployment. (shrink)

Recently in the pages of The Classical Quarterly Mathias Hanses convincingly demonstrated the existence of a fourth occurrence of the programmatic adjective λεπτός in Aratus, Phaen. 783–7. This new example occurs in the form of a diagonal acrostic alongside the known ‘gamma-acrostic’ and the occurrence of the same form of the adjective in line 784. Jerzy Danielewicz has now proposed yet a fifth instance of λεπτή in the form of an acronym spread over two lines and meant to be read (...) anticlockwise. (shrink)

I respond to Vladas Griskevicius and Douglas T. Kendrick (G&K) and Gad Saad's (S) defenses of the view that Consumer Studies would benefit from the appeal to evolution in all work aimed at understanding consumer behavior. I argue that G&K and S's reliance on one theoretical perspective, that of evolutionary psychology, limits their options. Further, I point out some specific problems with the theoretical perspective of evolutionary psychology. Finally, I introduce some alternative evolutionary approaches to studying human behavior that could (...) profitably be adopted in consumer research. -/- . (shrink)

ABSTRACT:Many of humanity's most serious problems are global, intergenerational, and ecological, yet current institutions are poorly placed to confront such problems. In part, this institutional challenge reflects difficulties with our basic concepts and theories. Bioethics is a central area where such questions arise. Although some have argued for an environmentalized bioethics since its inception, biomedicine has thus far failed to embrace the challenge, and some accuse most bioethicists of being "asleep at the wheel" (Schenck and Churchill 2021). This paper discusses (...) the basic ethical challenge, offers the "perfect moral storm" analysis, and explores one promising new concept for bioethics, planetary health, in light of that analysis. Drawing on the foundational report of the Rockefeller Foundation–Lancet Commission (Whitmee et al. 2015) and using climate change as the example, the author argues that planetary health has significant strengths but also some weaknesses, and that identifying both is helpful in charting a path forward for environmentalized bioethics. (shrink)

Geoengineering is commonly defined as ‘the deliberate large-scale manipulation of the planetary environment to counteract anthropogenic climate change’. Technologies which...

This article attempts to reconstruct an early history of the Norwegian Pentecostal Mission’s work in Kenya. The Free Pentecostal Church, known as the Free Pentecostal Fellowship in Kenya until April 2018, was born out of a 1984 merger between the Swedish Free Mission and the NPM. The Norwegians came earlier in 1955, whereas their Scandinavian counterparts arrived in 1960. The article contests that during the period under review, the first 29 years of NPM’s presence in Kenya, the NPM was characterised (...) by a fast-growing enthusiasm in establishing mission stations and local churches through evangelism and social work activities in education, medical care, orphanages, midwifery and compassionate handouts of commodities to villagers. These would be overtaken by the efforts to merge Swedish and Norwegian interests and establishments into one denomination in 1976 and the move towards nationalising the FPFK by handing over church leadership to the Kenyans by 1997. The article contests that the zeal and successes of the missionaries and local church workers in sowing the seeds of the gospel were checked by cultural and socio-economic setbacks in Kenya’s colonial context as well as the nationalisation process. The increased presence of Norwegian missionaries in Kenya during the 1960s were largely motivated by, among other factors, the channelling of Norwegian government aid monies to foreign development regions through missionary agencies and the imminent independence of the East African state. (shrink)

What might a theory of mental imagery look like, and how might one begin formulating such a theory? These are the central questions addressed in the present paper. The first section outlines the general research direction taken here and provides an overview of the empirical foundations of our theory of image representation and processing. Four issues are considered in succession, and the relevant results of experiments are presented and discussed. The second section begins with a discussion of the proper form (...) for a cognitive theory, and the distinction between a theory and a model is developed. Following this, the present theory and computer simulation model are introduced. This theory specifies the nature of the internal representations (data structures) and the processes that operate on them when one generates, inspects, or transforms mental images. In the third, concluding, section we consider three very different kinds of objections to the present research program, one hinging on the possibility of experimental artifacts in the data, and the others turning on metatheoretical commitments about the form of a cognitive theory. Finally, we discuss how one ought best to evaluate theories and models of the sort developed here. (shrink)

In this paper I briefly introduce work on ancient-DNA and give some examples of the impact this work has had on responses to questions in archaeology. Next, I spell out David Reich’s reasons for his optimism about the contribution aDNA research makes to archaeology. I then use Robert Chapman and Alison Wylie’s framework to offer an alternative to Reich’s view of relations between aDNA research and archaeology. Finally, I develop Steven Mithen’s point about the different questions archaeologists and geneticists ask, (...) arguing that different disciplinary perspectives color researchers’ perceptions of “the most important questions” or the “central topics” in a field. I conclude that evidence from aDNA research cannot solve archaeological disputes without closer, mutually respectful collaboration between aDNA researchers and archaeologists. Ancient DNA data, like radiocarbon data, is not a silver bullet for problems in archaeology. (shrink)

I pose problems for the views that human nature should be the object of study in the social and behavioral sciences and that a concept of human nature is needed to guide research in these sciences. I proceed by outlining three research programs in the social sciences, each of which confronts aspects of human variation. Next, I present Elizabeth Cashdan and Grant Ramsey’s related characterizations of human nature. I go on to argue that the research methodologies they each draw on (...) are more productive resources for social scientists than their competing characterizations of human nature. (shrink)